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    Annemarie C. Brescia, MD

    Division Chief
    Provider Profile

    ÀÖ²¥´«Ã½ Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

    Biography

    AnneMarie Brescia, MD, FAAP, FACR, obtained a BS in Chemistry from Fordham University, during which time she was elected to Phi Beta Kappa and graduated Magna cum laude. She then conducted synthetic organic chemistry research for which she was granted two US patents. While pursuing graduate studies in Chemistry, she decided to enroll in medical school. She received her medical education at the New York University (NYU) School of Medicine in 1998. She then completed her internship and residency training in Pediatrics at St Christopher's Hospital for Children in Philadelphia. The research years of her fellowship were conducted in the National Institute of Arthritis, Musculoskeletal and Skin Research at the NIH. After completing fellowship training in pediatric rheumatology at Thomas Jefferson University/ AI duPont Hospital for Children, she became faculty of that institution and is currently Chief of the Division of Pediatric Rheumatology. She is board certified in both general pediatrics and pediatric rheumatology. Dr Brescia divides her time between clinical care and translational research. She is also the fellowship director of the pediatric rheumatology training program at Thomas Jefferson University/ AI duPont Hospital for Children. Her research interests include juvenile idiopathic arthritis (JIA). She has ongoing projects investigating differential gene expression profiles of synoviocytes (cells which line the joints) in JIA. The main goal of her research program is to identify synovial fluid biomarkers (proteins) which can predict course and prognosis in JIA.

    Fellowship

    • Pediatric Rheumatology - ÀÖ²¥´«Ã½/Alfred I. duPont Hospital for Children, 2004

    Residency

    • Pediatrics - St. Christopher's Hospital for Children, 2001

    Education

    • M.D. - New York University, 1998

    Board Certifications

    • American Board of Pediatrics/General Pediatrics
    • American Board of Pediatrics/Rheumatology

    • Juvenile Arthritis
    • Rna Sequencing
    • Synoviocytes

    • Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis; Pediatric Rheumatology; (2024).

    • CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment; Rheumatology (United Kingdom); (2023).

    • Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis; Rheumatology and Therapy; (2023).

    • Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype; Arthritis Research and Therapy; (2022).

    • An Atypical Case of Scurvy in an Adolescent With Sacroiliitis; Clinical Pediatrics; (2022).

    • The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes; Pediatric Rheumatology; (2021).

    • Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation; Pediatric Rheumatology; (2020).

    • Juvenile Idiopathic Arthritis Fibroblast-like Synoviocytes, through BMP signaling, play a central role in joint growth disturbances; Research Square; (2020).

    • Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases; Journal of Clinical Investigation; (2020).

    • Prior to extension, transcriptomes of fibroblast-like synoviocytes from extended and polyarticular juvenile idiopathic arthritis are indistinguishable; Pediatric Rheumatology; (2018).

    • Unilateral Periorbital Swelling in Two Previously Healthy Females; Global Pediatric Health; (2017).

    • Secretion of pro-inflammatory cytokines and chemokines and loss of regulatory signals by fibroblast-like synoviocytes in juvenile idiopathic arthritis; Proteomics - Clinical Applications; (2017).

    • The role of transforming growth factor β signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor β signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy.; Arthritis & rheumatology (Hoboken, N.J.); (2014).

    • Lyme chondritis presenting as painless ear erythema; Pediatrics; (2013).

    • Prognostic Impact of Atypical Presentation in Pediatric Systemic Lupus Erythematosus: Results from a Multicenter Study; Journal of Pediatrics; (2010).

    • Prolonged synovitis in pediatric lyme arthritis cannot be predicted by clinical or laboratory parameters; Clinical Rheumatology; (2009).

    • Focus on Subspecialties, Importance of Immunizations:; AAP News; (2009).

    • Predicting duration of beneficial effect of joint injection among children with chronic arthritis by measuring biomarkers concentration in synovial fluid at the time of injection; Clinical and Experimental Rheumatology; (2008).

    • Steady improvement of prothrombin levels after cyclophosphamide therapy in pediatric lupus anticoagulant hypoprothrombinemia syndrome (LAHPS); Clinical Rheumatology; (2007).

    • Joint Swelling; Pediatrics on Call; (2006).

    • Process for the Preparation of Bis(Amidocarboxylic Acids); Unknown Source; (1995).

    • Process for the Prepartion of Bis(Amidocarboxylic Acid); Unknown Source; (1995).

    • One-pot synthesis of cyclic amidinium tetrafluoroborates and hexafluorophosphates; the simplest models of N5, N10-methenyl-tetrahydrofolate coenzyme; Tetrahedron Letters; (1991).