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Sonali P Barwe

Sr Research Scientist

ÀÖ²¥´«Ã½ Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

Dr. Barwe is a Senior Research Scientist heading the Cancer Modeling Laboratory at ÀÖ²¥´«Ã½. After completing her Postdoc at UCLA, she joined ÀÖ²¥´«Ã½ in 2007. Her research is focused on deciphering the role of the bone marrow microenvironment in therapy resistance and identifying means to reverse it. Dr. Barwe works on developing patient-derived xenograft models of pediatric leukemia for preclinical drug evaluation with the goal of transitioning to the clinic. She also mentors UD graduate students and co-directs the ÀÖ²¥´«Ã½ Summer Undergraduate Research Program.

Education

  • MSc - University of Mumbai, 1997
  • PhD - Indian Institute of Science, Biochemistry, 2001

  • Chemosensitization
  • Epigenetic Drugs
  • Leukemia
  • Patient-Derived Xenografts

  • Bone Marrow Microenvironment-Induced Chemoprotection in <i>KMT2A</i> Rearranged Pediatric AML Is Overcome by Azacitidine–Panobinostat Combination; Cancers; (2023).

  • Imetelstat Induces Leukemia Stem Cell Death in Pediatric Acute Myeloid Leukemia Patient-Derived Xenografts; Journal of Clinical Medicine; (2022).

  • Mesothelin: An Immunotherapeutic Target beyond Solid Tumors; Cancers; (2022).

  • Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia; Journal of Clinical Medicine; (2022).

  • Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of <i>GATA1</i> and <i>STAG2</i> Mutations in Induced Pluripotent Stem Cells with Trisomy 21; Cells; (2022).

  • Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies; Cancers; (2021).

  • Harnessing the Power of Induced Pluripotent Stem Cells and Gene Editing Technology: Therapeutic Implications in Hematological Malignancies; Cells; (2021).

  • CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia.; Blood advances; (2020).

  • Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples.; Genomics & informatics; (2020).

  • Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer.; Frontiers in oncology; (2020).

  • Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring.; BMC medical genomics; (2020).

  • The extracellular matrix: A key player in the pathogenesis of hematologic malignancies.; Blood reviews; (2020).

  • Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology.; Molecular therapy. Methods & clinical development; (2020).

  • Effect of Ara-C on T-Cell Function and Flotetuzumab Activity in Pediatric Acute Myeloid Leukemia; Blood; (2019).

  • A Hydrogel Based 3D Culture System for Hematopoietic Differentiation of Induced Pluripotent Stem Cells; Blood; (2019).

  • Abstract LB-322: Identification of a novel fusion protein SPTAN1-ABL1 in a child with T-cell acute lymphoblastic leukemia: Functional characterization and therapeutic implications; Tumor Biology; (2019).

  • Mesothelin Targeting Bites for Pediatric AML: In Vivo Efficacy and Specificity; Blood; (2019).

  • Generation, Characterization and Pre-Clinical Drug Evaluation of Patient-Derived Xenograft Models of Pediatric Down Syndrome AML; Blood; (2019).

  • In Vivo Evaluation of Mesothelin As a Therapeutic Target in Pediatric Acute Myeloid Leukemia; Blood; (2019).

  • Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia.; Leukemia research; (2017).

  • Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells.; The Journal of biological chemistry; (2017).

  • Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.; Seminars in oncology; (2017).

  • Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia.; Leukemia research; (2017).

  • Generation of Pediatric Leukemia Xenograft Models in NSG-B2m Mice: Comparison with NOD/SCID Mice.; Frontiers in oncology; (2016).

  • Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.; PloS one; (2015).

  • Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.; Molecular cancer; (2015).

  • Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration.; American journal of physiology. Cell physiology; (2015).

  • Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.; PloS one; (2015).

  • Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling.; The Journal of biological chemistry; (2015).

  • Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity; Cancer & Metabolism; (2014).

  • Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma.; Cancer medicine; (2014).

  • Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells.; Molecular cancer therapeutics; (2013).

  • Regulation of Na,K-ATPase β1-subunit in TGF-β2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells.; Experimental eye research; (2013).

  • Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine.; Molecular pharmaceutics; (2012).

  • Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells.; Journal of cell science; (2012).

  • Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor.; Experimental cell research; (2011).

  • Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.; Journal of molecular and cellular cardiology; (2009).

  • Expression of Na,K-ATPase-beta(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin.; Cancer chemotherapy and pharmacology; (2009).

  • alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.; Molecular cancer therapeutics; (2008).

  • Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2.; International journal of oncology; (2007).

  • Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix.; International journal of oncology; (2007).

  • Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells.; Cellular and molecular biology (Noisy-le-Grand, France); (2006).

  • Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization.; Journal of molecular biology; (2006).

  • Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells.; American journal of physiology. Gastrointestinal and liver physiology; (2006).

  • Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature.; Microvascular research; (2006).

  • Multiple functions of Na,K-ATPase in epithelial cells.; Seminars in nephrology; (2005).

  • Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.; Molecular biology of the cell; (2004).

  • HLA class I signal transduction is dependent on Rho GTPase and ROK.; Biochemical and biophysical research communications; (2004).

  • The requirements for Ca2+, protein phosphorylation and concurrent protein synthesis for zeatin signaling of acidic chitinase transcript accumulation in Cucumis sativus L.; Journal of Plant Physiology; (2001).